Broadly, Dr. Mackey’s current research falls into two categories: characterizing central nervous system mechanisms of the human pain experience and its modulation and using this to develop biomarkers and development and use of an open-source learning healthcare system (CHOIR) to transform the care of people with pain, and serve as a platform for innovative research in real-world clinic patients. Additionally, Dr. Mackey and his team are investigating novel therapies for pain including transcranial magnetic stimulation, virtual reality, psychological and pharmacological therapies.