Dr. Mackey has served as principal investigator on multiple National Institutes of Health (NIH) awards (P01, multiple R01’s, U01, K24, T32). Additionally, Dr. Mackey holds two endowments that provide flexible research funds to pursue innovative projects and support junior investigators.

He is the author of over 200 journal articles and book chapters in addition to numerous national and international lectures. Broadly, some of Dr. Mackey’s current research falls into two categories:

  1. Characterizing central nervous system mechanisms of the human pain experience and its modulation and using this to develop biomarkers
  2. Development and use of an open-source learning healthcare system (CHOIR) to transform the care of people with pain, and serve as a platform for innovative research in real-world clinic patients.

Additionally, Dr. Mackey and his team are investigating novel therapies for pain including transcranial magnetic stimulation, virtual reality, psychological and pharmacological therapies.